Nanomedicine, from the ground up

A ten-part series on what the nanoscale is, why materials behave differently there, and how that science became medicine. 

Each post assumes only what the ones before it covered, so start at the top:

1. There's plenty of room at the bottom. What the nanoscale is, why gold turns red there, and where the field actually came from. 
2. Where nano meets life. Protein coronas, biological nanomachines, and what changes once a particle enters the body. [in preparation]
3. What is nanomedicine? From the first approved nanomedicine in 1995 to the delivery mechanisms behind today's products. [in preparation]
4. Lipid-based nanocarriers. Liposomes, lipid nanoparticles, NLCs and nanoemulsions, and how they came to carry mRNA. [in preparation]
5. Beyond lipids. Polymeric, metallic and hybrid nanoparticles, and what each does that lipids cannot. [in preparation]
6. The next generation of architectures. Polymersomes, nanofibers, nanodiscs, dendrimers and exosomes. [in preparation]
7. Where nanomedicine is used. Oncology, infection, the brain, the heart, the lung, and tissue repair. [in preparation]
8. When packaging changed the drug. Five products whose nanoformulation changed what the medicine could do. [in preparation]
9. The nucleic acid revolution. How nanoparticles made RNA medicine possible, from Onpattro to the COVID vaccines. [in preparation]
10. Seeing and treating at once. Diagnostics, imaging agents and theranostics that do both jobs in one particle. [in preparation]

Principal nanoformulation designs and the criteria behind them, their defining characteristics, CMC considerations, and the outcomes typically achieved. Written for pharmaceutical scientists and product developers.

A working reference on the materials themselves: lipid and phospholipid libraries, biopolymers and hydrogels, hybrid molecules, and excipients. What each one offers, the properties that distinguish it, and the technical advantages it brings to a nanoformulation.

Commentary on approvals, trial results, regulatory developments and debates shaping the field.